@echtra_bean I figured out how to reproduce this issue. I can get the game to crash everytime when I do the following.
Crash Reproduction Steps
This seems to be related to Spirit Well skill for Dusk Mage and Machineworks Dungeon in Act 3.
Start game without headphones plugged in to computer
Log in with lvl 38 Dusk Mage
Take Waypoint to Perilous Climb in Act 3
Go to Machineworks Dungeon (can only get it to crash here so far)
Cast Level 10 Spirit Well to summon minons
Plug in headphones to computer, and the game stutters
Try and move the character while game is stuttering, and the game will crash.
I can only reproduce this issue after I cast the Spirit Well skill and while in the Machineworks Dungeon. I tried to carsh the game in the same manner without Spirit Well minions and in other dungeons, and could not crash the game. The game still stutters, but was able to recover.